PROPER USE AND CARE
SMALL DOGS – FOR DOGS & PUPPIES OVER 6 WEEKS OF AGE AND UP TO 25 LBS
1 flavored chewable per month with 68 mcg Ivermectin/57 mg Pyrantel
MEDIUM DOGS – FOR DOGS & PUPPIES OVER 6 WEEKS OF AGE BETWEEN 26 TO 50 LBS
1 flavored chewable per month with 136 mcg Ivermectin/114 mg Pyrantel
LARGE DOGS – FOR DOGS & PUPPIES OVER 6 WEEKS OF AGE BETWEEN 51 AND 100 LBS
1 flavored chewable per month with 272 mcg Ivermectin/227 mg Pyrantel.
(For dogs over 100 lbs, use the appropriate combination of these flavored chewables based on weight).
Remove one flavored chewable from the foil-backed blister card. Most dogs find the flavor so appealing that the product can be offered by hand. Alternatively, it may be added intact to a small amount of dog food or placed in the back of the dog’s mouth for forced swallowing. For easy administration, insert chewable into VetIQ®’s Pill Treat flavored soft chews and give to your pet.
Care should be taken to ensure the dog consumes the complete dose, and treated animals should be observed for a few minutes after administration to ensure that part of the dose is not lost or rejected. If it is suspected that any of the dose has been lost, redosing is recommended.
Heart Shield Plus® flavored chewables should be given at monthly intervals during the period of the year when mosquitoes potentially carrying infective heartworm larvae are active. The initial dose must be given within a month (30 days) after the dog’s first exposure to mosquitoes. The final dose must be given within a month (30 days) after the dog’s last exposure to mosquitoes.
When replacing another heartworm preventive product in a heartworm disease preventive program, the first dose of Heart Shield® Plus flavored chewables must be given within a month (30 days) of the last dose of the former medication.
If the interval between doses exceeds a month (30 days), the efficacy of ivermectin can be reduced. For optimal performance, the flavored chewable must be given once a month on or about the same day of the month. If treatment is delayed, immediate treatment with Heart Shield Plus® flavored chewables and resumption of the recommended dosing regimen minimizes the opportunity for the development of adult heartworms.
Heart Shield Plus® flavored chewables, given orally using the recommended dose and regimen, are effective against the tissue larval stage of D. immitis for a month (30 days) after infection and, as a result, prevent the development of the adult stage. Heart Shield Plus® flavored chewables are also effective against canine ascarids (T. canis, T. leonina) and hookworms (A. caninum, U. stenocephala, A. braziliense).
In a trial in client-owned dogs, Heart Shield Plus® flavored chewables were shown to be a palatable oral dosage form consumed at first offering by the majority of dogs.
Heart Shield Plus® flavored chewables are available in three dosage strengths for dogs of different weights. Each strength comes in a box of 6 tablets.
Federal (U.S.A.) law restricts this drug to use by or on the order of a licensed veterinarian.
PRECAUTIONS AND WARNINGS
All dogs should be tested for existing heartworm infection before starting treatment with Heart Shield Plus® flavored chewables, which are not effective against adult D. immitis. Infected dogs must be treated to remove adult heartworms and microfilariae before initiating a program with Heart Shield Plus® flavored chewables.
While some microfilariae may be killed by the ivermectin in Heart Shield Plus® flavored chewables at the recommended dose level, Heart Shield Plus® flavored chewables are not effective for microfilariae clearance. A mild hypersensitivity-type reaction presumably due to dead or dying microfilariae, particularly involving a transient diarrhea, has been observed in clinical trials with ivermectin alone after treatment of some dogs that have circulating microfilariae.
KEEP THIS AND ALL DRUGS OUT OF THE REACH OF CHILDREN. In case of ingestion by humans, contact a physician immediately. Physicians may contact a Poison Control Center for advice concerning cases of ingestion by humans.
Store at controlled room temperature of 59 – 86°F (15-30°C)
Protect product from light.
Use product on or before its expiration date. Discard unused tablets.
In clinical trials with ivermectin/pyrantel, vomiting or diarrhea within 24 hours of dosing was rarely observed (1.1% of administered doses). The following adverse reactions have been reported following the use of ivermectin: Depression/lethargy, vomiting, anorexia, diarrhea, mydriasis, ataxia, staggering, convulsions, and hypersalivation.
Studies with ivermectin indicate that certain dogs of the Collie breed are more sensitive to the effects of ivermectin administered at elevated dose levels (more than 16 times the target use level of 6 mcg/kg) than dogs of other breeds. At elevated doses, sensitive dogs showed adverse reactions which included mydriasis, depression, ataxia, tremors, drooling, paresis, recumbency, excitability, stupor, coma and death. Ivermectin demonstrated no signs of toxicity at 10 times the recommended dose (60 mcg/kg) in sensitive Collies. Results of these trials and bioequivalency studies support the safety of ivermectin products in dogs, including Collies, when used as recommended.
Ivermectin/Pyrantel has shown a wide margin of safety at the recommended dose level in dogs, including pregnant or breeding bitches, stud dogs, and puppies aged 6 or more weeks. In clinical trials, many commonly used flea collars, dips, shampoos, anthelmintics, antibiotics, vaccines, and steroid preparations have been administered with ivermectin/pyrantel in a heartworm disease prevention program.
In one trial, where pups had parvovirus, there was a marginal reduction in efficacy against intestinal nematodes, possibly due to a change in intestinal transit time.
Why Choose Heart Shield Plus®?
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